In the early 2000’s, the use of PRP (Platelet-Rich Plasma) extended into orthopedics to boost healing in bone grafts and fractures. Continued success encouraged its use in sports medicine for connective tissue repair.
PRP (Platelet-Rich Plasma) contains growth factors that heal damaged tissues; and it works by naturally triggering an immune response, collagen production, and other regenerative processes. This helps heal/regenerate the area(s) of the body into which it’s injected. It is a commonly used therapy for healing injuries and arthritic joints, and is often combined with Prolozone®. (Click here to read our page on Prolozone®.)
Blood is drawn from the patient and added to a centrifuge to isolate the platelets, creating PRP (platelet rich plasma). PRP treatments work by supplying injured areas with natural proteins, cytokines, and other bioactive growth factors. PRP contains growth factors, and is an effective regenerative therapy used in all the Vampire Procedure® applications. (Please check out the info on our site about Vampire Wing Lifts®, Vampire Breast Lifts®, and Vampire Hair Restoration®, all of which use PRP, as well!)
Please see the footnotes below for references to some of the research done on the science and efficacy of PRP.
Platelet Rich Plasma (PRP) Scientific References
Review of Existing Science
Marx RE, Platelet-rich plasma: evidence to support its use, Journal of Oral and Maxillofacial Surgery 2004 62 (4): 489–96. doi:10.1016/j.joms.2003.12.003. PMID 15085519. Dentistry, 10x concentrate best, shows Harvest machine produces highest concentration
Christopher Allan Webb, PA-C, Platelet-Rich Plasma Update: Clinical Use in Musculoskeletal Care, Journal of Musculoskeletal Medicine, 2012; 29:96-101, mixed reviews, a number of positive studies but more are needed.
Randomized / Blind / Controlled Trials
Mishra AK, MD et al., Platelet Rich Plasma Significantly Improves Clinical Outcomes in Patients With Tennis Elbow, A Double-Blind, Prospective, Multicenter, Controlled Trial of 230 Patients, presented at the American Association of Orthopedic Surgeons (AAOS) in Chicago, Mar. 21, 2013, Tendon: Tennis Elbow; 71% improvement at 24 months.
Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T, Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up, American Journal of Sports Medicine, 2010;38:255-262, Tendon: (Chronic Lateral) Epicondylitis; 73% lasting success with PRP.
Vogrin M, Rupreht M, Crnjac A, et al., The effect of platelet-derived growth factors on knee stability after anterior cruciate ligament reconstruction: a prospective randomized clinical study, Wien Klin Wochenschr. 2010;122(suppl 2):91-95, ACL; significantly better knee stability with PRP.
Wassim Raffoul, PD, Effect of Platelet Rich Plasma and Keratinocyte Suspensions on Wound Healing, ClinicalTrials.gov Identifier: NCT00856934, January/February 2009, Wound healing; PRP + keratinocytes dramatically reduces healing times (50%) and pain (80-95%) if sprayed on wound dressings.
- Clinicaltrials.gov: 109 PRP trials listed at time of search in 2013, only 36 completed, around 10 of them not PRP relevant, so really only 26 trials with results:
Most trials found that PRP reduces pain, at least in the short term. Some found that it greatly diminishes the rate of re-tears and probably strengthens structural integrity.
2 trials found that PRP helps collagen generation in skin and also helps diminish nasolabial folds.
1 trial found significant pain reduction and cure in chronic (tennis) elbow tendinosis.
1 trial found faster return to activity after Achilles tendon tear repairs (part of surgery).